3-Hydroxy-3-Methylglutaric acid and triton-induced hyperlipidemia in rats |
| |
Authors: | S Y K Yousufzai M Siddiqi |
| |
Institution: | (1) Biochemistry Division, Chemistry Department, Aligarh Muslim University, 202001 Aligarh, (India) |
| |
Abstract: | Summary 3-Hydroxy-3-methylglutaric acid (HMG) significantly decreased cholesterol, triglyceride and phospholipid levels in whole serum, serum -lipoproteins and liver of Triton-induced hyperlipidemic rats. Therapeutically 50 mg HMG/kg is equivalent to 200 mg nicotinic acid/kg in lowering all these lipid parameters. HMG may exert its hypolipidemic effect through inhibition of lipoprotein synthesis.Acknowledgments. We are grateful to Dr.M. Saleemuddin for encouragement, Dr.P. E. Schurr, Upjohn Co. USA for generous gift of Triton W. R 1339 and Lady Tata Memorial Trust (India) for financial assistance to one of us (SYKY). |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|