| 三分子(叠氮化钠、炔烃、乙酸酯)反应合成1,4-二取代-1,2,3-三氮唑 |
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| 引用本文： | 李海根,熊知行. 三分子(叠氮化钠、炔烃、乙酸酯)反应合成1,4-二取代-1,2,3-三氮唑[J]. 云南大学学报(自然科学版), 2011, 33(4): 449 |
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| 作者姓名： | 李海根 熊知行 |
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| 作者单位： | 宜春学院化学与生物工程学院江西省高等学校应用化学与化学生物学重点实验室;宜春学院应用化学研究所; |
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| 基金项目： | 江西省高校重点实验室科技计划项目资助(赣财教GJJ[2007]431号) |
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| 摘 要： | 用三分子反应合成了1,4-二取代-1,2,3-三氮唑.碘化亚铜催化叠氮化钠、炔烃、乙酸酯三分子反应合成1,4-二取代-1,2,3-三氮唑,产率82%~92%。在该点击化学过程中无需直接使用有机叠氮化物,整个点击过程环境友好、安全、产率高.
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| 关 键 词： | 1,4-二取代-1,2,3-三氮唑 点击化学 乙酸酯 |
| 收稿时间： | 2011-03-21 |
Three-molecule(sodium azide,alkynes and acetic ester)reaction synthesised of 1,4-disubstituted 1,2,3-triazoles |
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| LI Hai-gen,XIONG Zhi-xin. Three-molecule(sodium azide,alkynes and acetic ester)reaction synthesised of 1,4-disubstituted 1,2,3-triazoles[J]. Journal of Yunnan University(Natural Sciences), 2011, 33(4): 449 |
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| Authors: | LI Hai-gen XIONG Zhi-xin |
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| Affiliation: | LI Hai-gen,XIONG Zhi-xin(College of Chemistry and Bioengineering,Key Laboratory of Jiangxi University for Applied Chemistry andChemical Biology,Institute of Applied Chemistry,Yichun University,Yichun 336000,China) |
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| Abstract: | Triazole is an important organic compound.In this article,we synthesised 1,4-disubstituted-1,2,3-triazoles with three molecule reaction.A three-molecule reaction was used to prepare a series of 1,4-disubstituted -1,2,3-triazoles from corresponding sodium azide,alkynes and acetic ester via CuI catalyst,with a yield of 82%—92%.This click process eliminates the need to handle organic azides and make this process even more friendly,safe and high efficiency. |
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| Keywords: | 1 4-disubstituted-1 2 3-triazoles click chemistry acetic ester |
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