| 四逆汤中3种双酯型生物碱含量对比研究 |
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| 引用本文： | 马雪玮,傅超美,李莹,聂英军,章津铭.四逆汤中3种双酯型生物碱含量对比研究[J].成都大学学报(自然科学版),2013,32(3):232-234. |
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| 作者姓名： | 马雪玮 傅超美 李莹 聂英军 章津铭 |
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| 作者单位： | 成都中医药大学药学院,中药材标准化教育部重点实验室,四川成都611137;澳门大学中华医药研究院,澳门氹仔,000853 |
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| 摘 要： | 采用LC-MS技术测定并比较了在四逆汤中附子与甘草配伍前后3种双酯型生物碱含量的变化.实验结果表明,缺甘草四逆汤中3种双酯型生物碱含量是四逆汤中3种双酯型生物碱含量的2倍或更多,且存在显著性差异(P<0.01),附子配伍甘草后,其主要毒性成分——3种双酯型生物碱的含量显著降低.
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| 关 键 词： | 四逆汤 附子 甘草 双酯型生物碱 LC-TOF/MS |
Comparative Study on Three Types of Double Ester Alkaloids Contents in Sini Decoction (SND) |
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| MA Xuewei
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FU Chaomei
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LI Ying
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NIE Yingjun
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ZHANG Jinming.Comparative Study on Three Types of Double Ester Alkaloids Contents in Sini Decoction (SND)[J].Journal of Chengdu University (Natural Science),2013,32(3):232-234. |
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| Authors: | MA Xuewei FU Chaomei LI Ying NIE Yingjun ZHANG Jinming |
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| Institution: | 1. College of Pharmacy, The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicines, Chengdu University of TCM, Chengdu 611137, China; 2.Chinese Medicine Research Institute, Macao University, Macao Special Administrative Region 000853, China) |
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| Abstract: | In this paper, LC-MS is adopted to compare the contents of three kinds of double ester alkaloids in SND before and after the compatibility of radix glycyrrhizae. The experimental results show that the cont- ents of three kinds of double ester alkaloids in SND with glycyrrhiza are 2 times or more than that in SND without glycyrrhiza,and there are significant differences（P 〈 0.01）. After the compatibility of glycyrrhizae in SND, the contents of main toxic components-three kinds of double ester alkaloids decrease significantly. |
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| Keywords: | sini decoction（SND） radix aconiti lateralis preparata radix glycyrrhizae double ester alka- loids LC-TOF/MS |
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