Regulation and dysregulation of astrocyte activation and implications in tumor formation |
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Authors: | Chunzhang Yang Shervin Rahimpour Albert C H Yu Russell R Lonser Zhengping Zhuang |
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Institution: | 1. Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 3D20, Bethesda, Maryland, 20892-1414, USA 2. Neuroscience Research Institute, Key Laboratory of Neuroscience (Ministry of Education), Key Laboratory for Neuroscience (Ministry of Public Health), Department of Neurobiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing, China
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Abstract: | Astrocytic activation is a cellular response to disturbances of the central nervous system (CNS). Recent advances in cellular and molecular biology have demonstrated the remarkable changes in molecular signaling, morphology, and metabolism that occur during astrocyte activation. Based on these studies, it has become clear that the astrocyte activation process is regulated by a variety of signaling pathways, which result in metabolic support, wound healing and scar formation. While normal astrocyte activation pathways drive homeostasis and/or repair in the CNS, dysregulation of these pathways can lead to astrocyte abnormalities, including glioma formation with similar phenotypes as reactive astrocytes. We review the principle pathways responsible for astrocytic activation, as well as their potential contribution to tumor formation in the CNS. |
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