| 基于GO的酵母膜系统蛋白相互作用规律研究 |
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| 引用本文： | 蔡禄,裴智勇,季风,江威.基于GO的酵母膜系统蛋白相互作用规律研究[J].内蒙古大学学报(自然科学版),2010,41(1). |
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| 作者姓名： | 蔡禄 裴智勇 季风 江威 |
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| 作者单位： | 1. 内蒙古科技大学数理与生物工程学院,内蒙古,包头,014010;内蒙古科技大学生物工程与技术研究所,内蒙古,包头,014010
2. 内蒙古科技大学数理与生物工程学院,内蒙古,包头,014010 |
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| 基金项目： | 国家自然科学基金资助项目(60761001) |
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| 摘 要： | 引进描述蛋白质相互作用倾向性参数(PIRB),基于GO(Gene Ontology)和相关的数据库中蛋白质功能注释,对酿酒酵母部分膜蛋白相互作用规律进行了研究,构建了基于PIRB的蛋白质相互作用网络图.结果表明各类膜蛋白质之间的相互作用具有明显的偏向性.对这种偏向性的生物学含义作了简要探讨.
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| 关 键 词： | 蛋白质相互作用 基因本体 相对倾向性因子 膜蛋白 酿酒酵母 |
Study on Protein-protein Interactions of S.cerevisiae Membranes Based on Gene Ontology |
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| CAI Lu,PEI Zhi-yong,JI Feng,JIANG Wei.Study on Protein-protein Interactions of S.cerevisiae Membranes Based on Gene Ontology[J].Acta Scientiarum Naturalium Universitatis Neimongol,2010,41(1). |
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| Authors: | CAI Lu PEI Zhi-yong JI Feng JIANG Wei |
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| Institution: | 1.School of Mathematics/a>;Physics and Biological Engineering/a>;2.Institute of Bioengineering and Technology/a>;Inner Mongolia University of Science and Technology/a>;Baotou 014010/a>;China |
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| Abstract: | A parameter PIRB describing protein-protein interaction bias was defined.The law of S.cerevisiae's membrane proteins interacting was investigated based on the Gene Ontology (GO) and the GO annotation from a related database.The protein-protein interaction network based on PIRB was constructed.The results indicate that there exists obvious interaction bias among proteins.The biological implication was also been discussed briefly. |
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| Keywords: | protein-protein interactions(PPI) Gene Ontology protein-protein interactions relative bias(PIRB) membrane proteins S cerevisiae |
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