Antidiuretic effects of oxytocin in the Brattleboro rat |
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| Authors: | J. Lyness A. G. Robinson M. N. Sheridan D. M. Gash |
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| Affiliation: | (1) Department of Anatomy, University of Rochester School of Medicine, 14642 Rochester, New York, USA;(2) Department of Medicine, University of Pittsburgh School of Medicine, 15261 Pittsburgh, Pennsylvania, USA;(3) Department of Anatomy, Uniformed Services, University of the Health Sciences, 20814 Bethesda, Maryland, USA |
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| Abstract: | Summary The antidiuretic activity of oxytocin (OT) was measured in Brattleboro rats with congenital diabetes insipidus. A dose dependent antidiuretic response was found in animals receiving chronic infusions of 0.1  g/h, 1.0 g/h, and 5 g/h of OT. OT infused at the rate of 5 g/h over a 7-day period completely reversed the symptoms of diabetes insipidus. The results support the concept that OT serves as a weak agonist of vasopressin at the level of the kidney and at pharmacological levels exhibits antidiuretic activity. |
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| Keywords: | Oxytocin antidiuretic activity Brattleboro rats |
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