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Diethylmesoxalate hydrate,a new irreversible inhibitor of cholinesterases
Authors:G Voss  R Neumann
Institution:(1) Agrochemicals Division, Ciba-Geigy Ltd, CH-4002 Basel, (Switzerland)
Abstract:Summary Bovine erythrocyte acetylcholinesterase and human plasma cholinesterase are irreversibly inhibited by diethylmesoxalate hydrate, the inhibition potency being comparable to that of certain insecticidal organophosphates and carbamates. Insect cholinesterases, however, appear to be much less affected by diethylmesoxalate hydrate. The compound was also found to inhibit the hydrolysis of paraoxon by rabbit plasma A-esterase, but in a reversible mode.
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