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Comparison of the time courses of luteinizing hormone (LH) secretion rates during continuous stimulation by LH-releasing hormone (LH-RH) in vivo and in vitro |
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| Authors: | J de Koning A M I Tijssen J A M J van Dieten T R Koiter G A Schuiling G P van Rees |
| Institution: | (1) Department of Pharmacology of the University of Leiden, P.O. Box 9503, 2300 RA Leiden, (The Netherlands);(2) Department of Obstetrics and Gynecology, Academic Hospital, Oostersingel 59, 9713 EZ Groningen, (The Netherlands) |
| Abstract: | Summary The patterns of LH secretion during constant stimulation of the pituitary glands of estradiol-treated ovariectomized rats with a maximally stimulating amount of LH-RH in vivo and in vitro correspond with each other qualitatively and quantitatively. In vitro the changes with time of the LH secretion rate are somewhat retarded, especially the occurrence of desensitization. |
| Keywords: | Pituitary gland luteinizing hormone (LH) luteinizing hormone-releasing hormone (LH-RH) LH-RH releasing activity in vivo vs in vitro |
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