Cannflavin A and B,prenylated flavones fromCannabis sativa L. |
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| Authors: | M L Barrett A M Scutt F J Evans |
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| Institution: | (1) Department of Pharmacognosy, The School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX London, (England);(2) Present address: Dept. of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, Lincoln's Inn Fields, WC2A 3PN London;(3) Present address: Dept. of Oral and Maxillofacial Surgery, Institute of Dental Surgery, Grays Inn Road, WC1X 8LD London |
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| Abstract: | Summary Two novel prenylat flavones, termed Cannflavin A and B, were isolated from the cannabinoid free ethanolic extract ofCannabis sativa L. Both compounds inhibited prostaglandin E2 production by human rheumatoid synovial cells in culture.This communication is dedicated to the memory of the late Professor J. W. Fairbairn and the late Dr. J. T. Pickens. We are grateful to the Medical Research Council for a project grant and to Ms J. Elliot of King's College London for NMR spectra. |
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| Keywords: | Cannabis PGF2 inhibition non-cannabinoids |
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