性激素诱导大鼠前列腺增生的免疫组织化学研究

Ｗｉｓｔａｒ雄性大鼠６５只分为正常对照组和实验组．后者均做双侧睾丸摘除术，术后３周根据不同的处理方法分为单纯阉割组、雄激素（Ｔ）处理组和不同比例雌雄激素处理组．以免疫组化ＡＢＣ法观察大鼠前列腺腹叶（ＲＶＰ）内雄激素受体（ＡＲ）和雌激素受体（ＥＲ）含量的变化。结果表明ＲＶＰ内ＥＲ变化不明显，ＡＲ含量在各实验组不同：单纯阉割组动物ＡＲ逐渐减少，雌激素（Ｅ２）与Ｔ同时处理较单用Ｔ处理ＡＲ增加更为显著，Ｅ２增加ＲＶＰ内ＡＲ含量的这种作用须在大鼠体内Ｔ大于一定含量时方能实现。提示Ｅ２可通过增加ＲＶＰ内ＡＲ的含量协同Ｔ对ＲＶＰ正常及异常生长的调节作用，本文对这种效应进行了讨论。

An Immounohistochemical Study of Rat Prostate Hyperplasia by Sex Hormone induced

Sixty-five male Wistar rats weie seperated randomly into normal group and experimental group.The later were all castrated three prior to hormone treatment nd then deveded randomlyinto three groups according to the defference of treatment:castration (group 1),testosterone (group2)and variable proportion of estrogen and 'testosterone (group 3).The content of estrogen-andandrogen-receptors (ER and AR)in rat ventral prostrate (RVP)was observed with immnuohistochemicalABC method.lt was found that change of ER content in RVP wasn't significant,and that AR.s wasdefferent in each experimental group;1]content of AR in group 1 decreased gradually,2]increased morestrikingly in group 3 than group 2,which occured only when content of testosterone exceeding a certainlevel.It is suggested that estrogen could cooperate with testosterone in adjusting normal and abnormalgrowth of RVP by increasing content of AR.this effect was discussed in the article.