AMPA receptors: potential implications in development and disease |
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Authors: | Franciosi S |
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Institution: | (1) Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, 2176 Health Sciences Mall, Vancouver (British Columbia V6T 1Z3, Canada), Fax: +1 604 822 6012, e-mail: soniaf@interchange.ubc.ca, CA |
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Abstract: | α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptors are one type of ionotropic glutamate receptor involved
in rapid excitatory synaptic transmission. AMPA receptors have been increasingly implicated in long-term potentiation, and
recent evidence suggests that they may play a role in disorders affecting the nervous system. The finding that early in postnatal
development AMPA receptors are not expressed has lately been the focus of much attention. Resolving the factors involved in
AMPA receptor expression suggests that their induction is a developmentally regulated process with the possibility that alterations
in receptor expression may be correlated with pathology in neurological disorders. This paper provides an overview of factors
involved in AMPA receptor induction as well as of their role in plasticity and neuronal pathologies.
Received 5 December 2000; received after revision 12 January 2001; accepted 2 February 2001 |
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Keywords: | , AMPA, NMDA, electrophysiology, long-term potentiation, calcium, neurological disorders, |
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