| RhoE/Rnd3在肝癌组织中的表达及临床意义 |
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| 引用本文： | 张超,李杰,张洪涛,窦科峰.RhoE/Rnd3在肝癌组织中的表达及临床意义[J].科学技术与工程,2009,9(14). |
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| 作者姓名： | 张超 李杰 张洪涛 窦科峰 |
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| 作者单位： | 第四军医大学西京医院肝胆外科,西安,710032 |
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| 摘 要： | 通过观察RhoE/Rnd3在肝癌组织中的表达情况及其与临床病理分级的关系,为探索RhoE/Rnd3的生物学功能和临床意义提供依据。对166例组织标本(其中正常肝脏组织60例,原发性肝癌病人106例)利用免疫组化研究RhoE/Rnd3在组织中蛋白水平的表达变化。RhoE/Rnd3在正常肝脏组织中普遍表达,但在原发性肝癌组织中表达低下或缺失。免疫组化结果显示RhoE/Rnd3主要分布在细胞的胞浆中。RhoE/Rnd3在原发性肝癌组织中的表达(阳性率为78%,83/106),明显低于其在正常肝组织(阳性率为97%,58/60)。P<0.005。且RhoE/Rnd3的表达随肿瘤组织分化程度的降低染色强度有下降趋势(P<0.005)。RhoE/Rnd3在原发性肝癌组织中表达明显降低,表明其对肿瘤的发生发展起到负性调控作用,结合目前的研究结果,RhoE/Rnd3可能是一种新型的抑癌基因,参与肿瘤细胞的凋亡过程。
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| 关 键 词： | RhoE/Rnd3 肝癌 GTP结合蛋白 |
Expression of RhoE/Rnd3 in Hepatocellular Carcinoma and Clinical Significance |
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| ZHANG Chao,LI Jie,ZHANG Hong-tao,DOU Ke-feng.Expression of RhoE/Rnd3 in Hepatocellular Carcinoma and Clinical Significance[J].Science Technology and Engineering,2009,9(14). |
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| Authors: | ZHANG Chao LI Jie ZHANG Hong-tao DOU Ke-feng |
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| Institution: | Department of Hepatobiliary Surgery;Xijing Hospital;Fourth Military Medical University;Xi'an 710032;P.R.China |
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| Abstract: | To explore the expression and clinical significance of RhoE/Rnd3 in tumoral specimens from patients with hepatocellular carcinoma(HCC),immunohistochemistry was used to measure the RhoE/Rnd3 expressions of protein.Immunohistochemistry results showed that the positive expression of RhoE/Rnd3 was significantly lower in HCC(78%,83/106)as compared to normal liver tissues(97%,58/60),P<0.005.Normal tissues almost displayed cytoplasmic staining.Expression of RhoE/Rnd3 correlation with the differentiation degree of ... |
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| Keywords: | RhoE/Rnd3 hepatocellular carcinoma GTP binding protein |
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