阿尔茨海默症发病机制及治疗方法研究进展

 阿尔茨海默症（Alzheimer's disease，AD）是以β淀粉样蛋白斑块及神经元纤维缠结为主要病理特征的神经退行性疾病，是痴呆中最常见的一种，也是一种常见的老年人疾病。AD的发病机制可能由多种发病因素、多种通路和分子机制的相互参与引起。由于AD的发病主要同老年人有关，故研究治疗AD的方法对于提高人类健康和生活水平至关重要。虽然目前并没有一种治疗方法可以完全治愈AD，但有多种治疗策略。本文对AD的发病机制及治疗方法的研究进展进行简要综述。

Progress in pathogenesis and treatment of Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by two pathological hallmarks:β-amyloid plaques and neurofibrillary tangles. It is the most common type of dementia and a common disease of the elderly. The pathogenesis of AD is related to multiple risk factors, pathways and molecular mechanisms. Because AD is a disease that is currently widespread in the elderly, it is essential to figure out pharmaceutical strategy for AD in order for aged people to get healthy and quality life. There is no treatment method that can completely cure AD right now, but there are various treatment strategies. This article reviews briefly the past and recent important findings of pathogenesis and treatment strategies of AD.