Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas |
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| Authors: | Wu Gang,Broniscer Alberto,McEachron Troy A,Lu Charles,Paugh Barbara S,Becksfort Jared,Qu Chunxu,Ding Li,Huether Robert,Parker Matthew,Zhang Junyuan,Gajjar Amar,Dyer Michael A,Mullighan Charles G,Gilbertson Richard J,Mardis Elaine R,Wilson Richard K,Downing James R,Ellison David W,Zhang Jinghui,Baker Suzanne J St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project |
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| Affiliation: | Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. |
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| Abstract: | To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3.3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration. |
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