|
|||||
|
|
| 中国鲎鲎素T-1抗人早幼粒白血病HL-60细胞活性研究 | |
| 引用本文： | 洪水根,陈菲,李祺福,胡友川,叶军,欧阳高亮,李长友,李筱泉,乔玉欢,陈福.中国鲎鲎素T-1抗人早幼粒白血病HL-60细胞活性研究[J].厦门大学学报(自然科学版),1999,38(3):448-451. |
| 作者姓名： | 洪水根 陈菲 李祺福 胡友川 叶军 欧阳高亮 李长友 李筱泉 乔玉欢 陈福 |
| 作者单位： | 1. 厦门大学细胞生物学研究室,厦门,361005 2. 厦门大学化学系,厦门,361005 3. 厦门大学抗癌研究中心,厦门,361005 |
| 基金项目： | 福建省自然科学基金,厦门市海洋科技计划资助项目 |
| 摘 要： | 利用从中国鲎血细胞中提取的鲎素Ｔ－１作抗肿瘤活性实验．结果表明，鲎素Ｔ－１在体外对人早幼粒白血病ＨＬ－６０细胞的增殖有明显抑制作用．急性毒理实验显示，鲎素Ｔ－１对正常活体毒性较小，可用于活体实验．荷瘤裸鼠实验统计，鲎素Ｔ－１对肿瘤抑制率达４２．３％． |
| 关 键 词： | 中国鲎，鲎素T－1，人早幼粒白血病HL－60细胞 |
Study on Antitumor Activity of Tachypesin-I against Human Promyelocytic Leukemia Cell Line HL-60 from Hemocyte of Horseshoe Crab |
|
| Hong Shuigen,Chen Fei,Li Qifu,Hu Youchuan,Ye Jun,Ouyang Gaoliang,Li Changyou,Li Xiaoquan,Qiao Yuhuan,Chen Fu.Study on Antitumor Activity of Tachypesin-I against Human Promyelocytic Leukemia Cell Line HL-60 from Hemocyte of Horseshoe Crab[J].Journal of Xiamen University(Natural Science),1999,38(3):448-451. | |
| Authors: | Hong Shuigen Chen Fei Li Qifu Hu Youchuan Ye Jun Ouyang Gaoliang Li Changyou Li Xiaoquan Qiao Yuhuan Chen Fu |
| Abstract: | The antitumor activity of tachyplesin I(T 1) extracted from the hemocytes of horseshoe crab Tachypleus tridentatus for human promyelocytic leukemia cells line HL 60 has been studied. It was demonstrated that tachyplesin I had the remarkable inhibitory activity on proliferation of HL 60 cells in vitro experiment. The result from acute toxicological assay showed that tachyplesin I only had a little toxicity and could be used in intravital research. The rate of tumorous suppression of tachyplesin I reached to 42.3% on HL 60 cells. |
| Keywords: | Horseshoe crab Tachypleus tridentatus Tachyplesin I Human promyelocytic leukemia cell line HL 60 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |