基于TMAES对GrC神经元放电活动影响的仿真

经颅磁声电刺激（TMAES）是一种新型无创的脑神经调控技术，具有良好的应用前景.该技术利用静磁场和超声波共同作用所产生的磁声电效应，在神经组织中产生感应电流，进而对神经组织实施刺激.作者基于小脑颗粒细胞模型（GrC模型），建立了突触连接GrC模型，对TMAES刺激下突触连接GrC模型的动作电位进行仿真，分析了动作电位的传播方向.在TMAES神经元的不同突触连接方式下，对比了兴奋性与抑制性对神经元放电的影响.通过改变抑制点的位置分析了抑制作用在TMAES下对神经元放电模式的影响.仿真结果显示，经颅磁声电刺激对GrC模型神经元放电节律具有重要影响.实现了两个神经元突触连接模型在TMAES下的仿真，对进一步发掘和研究神经元的传导及连接模式具有重要意义.

Simulation Research on Cerebellar Granule Cell Discharge Activity Based on TMAES

Transcranial magneto-acoustical electrical stimulation (TMAES) is a new noninvasive technique for brain nerve regulation, presenting a great application prospect. In this technique, the magneto-acoustic effect excited by the interaction of static magnetic field and ultrasonic wave was utilized to generate inductive current in nerve tissue and stimulate nerve tissue. Firstly, a synaptic connection GrC model was established based on cerebellar granular cell model (GrC model), and the action potential of the synaptic connection GrC model stimulated by TMAES was simulated to analyze the propagation direction of the action potential. Secondly, the different positions of neurons were stimulated by changing the synaptic connections of neurons, and the effects of TMAES on excitatory and inhibitory action potentials were compared. Finally, the effect of inhibition on neuronal firing patterns under TMAES was analyzed by changing the position of the inhibition points. The simulation results show that transcranial magnetic acoustic stimulation has an important influence on the firing rhythm of neurons in GrC model. The simulation of two neuron synaptic connection models under TMAES was carried out, which presents a great significance for further exploration and study of neuron conduction and connection modes.