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| 阿奇霉素在鸡组织中的消除规律及临床毒性研究 | |
| 引用本文： | 徐晓虹,颜文钦,黄春贵,徐广伟.阿奇霉素在鸡组织中的消除规律及临床毒性研究[J].浙江师范大学学报(自然科学版),2007,30(2):146-151. |
| 作者姓名： | 徐晓虹 颜文钦 黄春贵 徐广伟 |
| 作者单位： | 1. 浙江师范大学,化学与生命科学学院,浙江,金华,321004 2. 白龙桥兽医站,浙江,金华,321000 3. 金华市质量技术监督检测院,浙江,金华,321000 |
| 摘 要： | 探讨了阿奇霉素对仔鸡的临床毒性及其在鸡组织中的消除规律.阿奇霉素以0、50、100和200 mg/L的水溶液供麻花肉鸡连续自由饮用14 d后,测定血清生化指标、脏器系数,并进行组织病理学观察;同时,阿奇霉素按10 mg/kg的剂量连续对肉鸡灌服7 d后测定体内各组织中的残留量.结果显示,高剂量组肉鸡的肝脏系数和谷丙转氨酶活性存在显著差异(P<0.05),阿奇霉素在肉鸡肝脏中的残留时间最长,其他依次是肾脏、脾脏、肌肉和血清.表明肉鸡的肝脏为阿奇霉素的中毒靶器官;根据其在鸡组织中的消除规律,阿奇霉素的肉鸡休药期可定为15 d. |
| 关 键 词： | 阿奇霉素 麻花肉鸡 临床毒性 残留 消除 |
| 文章编号： | 1001-5051（2007）02-0146-06 |
| 收稿时间： | 2007-03-23 |
| 修稿时间： | 2007年3月23日 |
Study on residue elimination in broiler tissues and clinical toxicity of Azithromycin |
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| XU Xiaohong,YAN Wenqin,HUANG Chungui,XU Guangwei.Study on residue elimination in broiler tissues and clinical toxicity of Azithromycin[J].Journal of Zhejiang Normal University Natural Sciences,2007,30(2):146-151. | |
| Authors: | XU Xiaohong YAN Wenqin HUANG Chungui XU Guangwei |
| Institution: | 1. College of Chemistry and Life Science, Zhejiang Normal University, Jinhua Zhejiang 321004, China; 2. Bailongqiao Veterinary Station, Jin- hua Zhejiang 321000, China; 3. Institute of Testing for Quality and Technical Supervision, Jinhua Zhejiang 321000, China |
| Abstract: | It was investigated the clinical toxicity of azithromycin in broilers and rule of the residue elimination.The activity of serum enzymes,viscera coefficients and pathologic changes were detected after the test were conducted for 14 days,with dose of 0,50,100,or 200 mg/L to Muhua broilers by free drinking.The residue concentrations of azithromycin were mensurated by feeding Mahua broilers with 10 mg/kg body weight for 7 days.The liver coefficient and the activity of alanine transaminase in 200 mg/L group increased significantly compared with the other groups(P<0.05).The residue levels of azithromycin from high to low were liver,kidney,spleen,muscle and serum.The toxic target organ of azithromycin was liver;and the concentrations of azithromycin in various tissues were below minimal risk levels(MRLs) after drug withdrawal of 15 days. |
| Keywords: | Azithromycin Mahua broilers clinical toxicity residue elimination |
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