| IGF-PI3K-Akt信号通路在生理性心肌肥大中的作用研究进展 |
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| 引用本文： | 马继政,孙飙,吕远远.IGF-PI3K-Akt信号通路在生理性心肌肥大中的作用研究进展[J].南京体育学院学报(自然科学版),2007,6(3):6-10. |
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| 作者姓名： | 马继政 孙飙 吕远远 |
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| 作者单位： | 1. 解放军理工大学军事系,江苏,南京,211101
2. 南京体育学院运动人体科学系,江苏,南京,210014 |
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| 摘 要： | 心肌肥大是心肌细胞对多种刺激因素的复杂反应。心肌肥大可以分为三种:心肌的正常生长、运动诱导生理性心肌肥大和病理性心肌肥大。近年来,研究表明心肌的正常生长以及运动诱导的心肌生理性肥大,主要是通过IGF-PI3K-Akt信号通路进行信号转导。本文就IGF-PI3K-Akt信号转导通路的结构特点、调节过程作一综述。
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| 关 键 词： | 生理性肥大 病理性肥大 IGF-PI3K-Akt信号通路 |
| 文章编号： | 1671-5950（2007）03-0006-05 |
| 修稿时间： | 2007-07-11 |
Research Development on Regulation of Cardiac Physiological Hypertrophy by the IGF - PI3K - Akt Signaling Pathway |
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| MA Ji-zheng,SUN Biao,LV Yuan-yuan.Research Development on Regulation of Cardiac Physiological Hypertrophy by the IGF - PI3K - Akt Signaling Pathway[J].Joournal of Nanjing Institute of Physical Education:Natural Science,2007,6(3):6-10. |
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| Authors: | MA Ji-zheng SUN Biao LV Yuan-yuan |
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| Institution: | 1. Department of Military Education and Training, the PLA University of Science and Technology, Nanjing, 211101, Jiangsu, China; 2. Department of Human Sports Science, Nanjing Institute of Physical Education, Nanjing, 210014, Jiangsu, China |
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| Abstract: | In broad terms, there are 3 types of cardiac hypertrophy: normal growth, growth induced by physical conditioning (i.e., physiologic hypertrophy), and growth induced by pathologic stimuli. Recent evidence suggests that normal and exercise-induced cardiac growth are regulated in large part by IGF-PI3K-Akt signaling pathway. In this review we will discuss the construction features and process of the IGF-PI3K-Akt signaling pathway in the heart. |
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| Keywords: | Physiologic hypertrophy Pathologic hypertrophy IGF-PI3K-Akt signaling pathway |
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