The NOTCH4 locus is associated with susceptibility to schizophrenia |
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| Authors: | Wei J Hemmings G P |
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| Affiliation: | Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bryn Hyfryd, The Crescent, Bangor, Gwynedd, UK. jwei@hgmp.mrc.ac.uk |
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| Abstract: | ![]()
Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia. |
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