Failure of coffee to inhibit the pharmacodynamic activity of morphine in vivo |
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Authors: | O Strubelt M Kaschube G Zetler |
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Institution: | (1) Institut für Toxikologie und Institut für Pharmakologie, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, D-2400 Lübeck, (Federal Republic of Germany) |
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Abstract: | Summary High doses of caffeine-containing as well as decaffeinated instant coffee neither inhibited morphine-induced analgesia in mice nor the morphine-induced fall of blood pressure, heart rate and respiratory rate in rats. On the contrary, caffeine-containing coffee even enhanced the analgesic effects of morphine in mice. Coffee thus does not exhibit opiate-antagonizing activity in the whole organism in vivo. The very weak morphine-antagonistic efficacy of coffee powder in the myenteric plexus-longitudinal muscle preparation from the guinea pig ileum is of no practical importance. |
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Keywords: | Coffee caffeine morphine naloxone analgesia |
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