Regulation of cell adhesion by PP2A and SV40 small tumor antigen: An important link to cell transformation |
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Authors: | J -M Sontag E Sontag |
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Institution: | (1) Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9073, USA |
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Abstract: | The serine/threonine protein phosphatase 2A (PP2A) represents a large family of highly conserved heterotrimeric enzymes. Their
critical importance in cell homeostasis is underlined by the fact that they are targets of natural toxins like the tumor promoter
okadaic acid, and of simian virus 40 small tumor antigen (SV40 small t), a viral protein known to promote cell transformation.
Furthermore, mutated or lower expression levels of PP2A subunits have been found in certain cancers. One major known event
in PP2A-dependent cell transformation is the alteration of key signaling pathways that control cell growth and survival. In
this review, we focus on how PP2A enzymes also affect cell adhesion and cytoskeletal dynamics, the disruption of which is
linked to loss of cell polarity, increased cell motility and invasiveness. We also examine how those various pathways participate
in the transforming activity of SV40 small t.
Received 29 June 2006; received after revision 3 August 2006; accepted 20 September 2006 |
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Keywords: | Phosphatase 2A SV40 small t transformation junction adhesion cytoskeleton |
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