| 杏仁对环磷酰胺和3－甲基胆蒽诱变性的抑制效应 |
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| 引用本文： | 赵景春,李京霞,罗漫,金向东,孙波.杏仁对环磷酰胺和3－甲基胆蒽诱变性的抑制效应[J].北京联合大学学报(自然科学版),1994(1). |
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| 作者姓名： | 赵景春 李京霞 罗漫 金向东 孙波 |
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| 作者单位： | 北京联合大学职业技术师范学院 |
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| 摘 要： | 本文以小鼠细胞ＳＣＥ和微核率为指标评价了杏仁对抗肿瘤药环磷酰胺和遗传毒物３－甲基胆蒽诱变性的抑制效应，发现中药杏仁无致突变性，而且，对上述两种强诱变剂均有抑制作用。实验结果说明杏仁对突变具有一定和防护作用，并提示杏仁有望成为肿瘤化疗药物毒副作用的拮抗剂。
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| 关 键 词： | 苦杏仁，微核，姊妹染色单体交换，抗肿瘤药，抗突变 |
A Study on Almonds Inhibition of Mutation Induced by Cyclophosphomidum(CP)And 3-Methylcholanthren |
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| Zhao Jingchun,Li Jingxia, Luo Man, Jin Xiangdong,Sun Bo.A Study on Almonds Inhibition of Mutation Induced by Cyclophosphomidum(CP)And 3-Methylcholanthren[J].Journal of Beijing Union University,1994(1). |
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| Authors: | Zhao Jingchun Li Jingxia Luo Man Jin Xiangdong Sun Bo |
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| Abstract: | By using sister chromatid exchange (SCE) and micronucleus(MN)as a marker, therelationship between the cyclophosphomidurn,3-methylcholanthren inducing effect and Chinesemedicine-almond protecting effect was studied in the Kumming mice.The results showed that al-mond itself have not the effect of inducing damages but have restraining effect to SCE and MNT in-duced by cyclopbosphomidum and 3-methylcholanthren. SCE and MN decrease significantly (P<0.01). This resuIts showed that almond seems to be able to protect genetic damages. |
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| Keywords: | almond micronticleus SCE antineoplastic drugs antimutagenesis |
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