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The Art of War: Innate and adaptive immune responses
Authors:P.?W.?Dempsey,S.?A.?Vaidya,G.?Cheng  mailto:genhongc@microbio.ucla.edu"   title="  genhongc@microbio.ucla.edu"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author
Affiliation:(1) Department of Microbiology, Immunology and Molecular Genetics, University of California, 10833LeConte Avenue, 90095 Los Angeles, California, USA
Abstract:
Research over the last several years has greatly advanced our understanding of the mechanisms by which the immune system functions. There exist two main branches of immunity, termed innate and adaptive immunity. Innate immunity uses the genetic memory of germline-encoded receptors to recognize the molecular patterns of common pathogens. Adaptive immunity, akin to somatic memory, is a complex system by which the body learns to recognize a pathogenrsquos unique antigens and builds an antigen specific response to destroy it. The effective development of the overall immune response depends on careful interplay and regulation between innate and adaptive immunity. Here we review our current understanding of how these integrated systems distinguish targets against which a response is appropriate and neutralize potentially pathogenic challenges.Received 8 May 2003; accepted 2 June 2003
Keywords:Pathogen recognition  innate activation  host defense  antigen presentation  immunoregulation
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