AXL and acquired resistance to EGFR inhibitors |
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| Authors: | Sophie Postel-Vinay Alan Ashworth |
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| Affiliation: | 1] Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research, London, UK. [2] Institut Gustave Roussy, Département de Médecine-Institut National de la Santé et de la Recherche Médicale (INSERM) U981, Villejuif, France. |
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| Abstract: | ![]()
A combination of in vitro and in vivo models with validation in human tumors has identified AXL activation as a new mechanism of acquired resistance to EGFR inhibitors in non-small cell lung cancer. The identification of this mechanism, alongside the current development of specific AXL inhibitors, provides the rationale for further studies that may improve treatment for EGFR inhibitor-resistant patients. |
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