青年男性尿液中多环芳烃代谢物与血液肝功能指标的关联研究

为了解青年男性多环芳烃暴露浓度与肝功能指标之间的关联,征集郑州地区121名志愿者进行了问卷调查和血液及尿液样品采集,分析了血液中丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、总蛋白(TP)、白蛋白(Alb)、球蛋白(Glo)以及白蛋白/球蛋白比值(A/G)等肝功能指标以及尿液中1-羟基芘(1-OHP)。采用相关系数、线性回归模型和逻辑斯蒂回归模型进行分析。结果发现郑州地区青年男性体内普遍存在多环芳烃暴露,尿液1-OHP浓度与AST之间存在弱的正相关关系,未在尿液1-OHP浓度与其他肝功能指标之间发现显著关联。

Associations between urinary polycyclic aromatic hydrocarbon metabolites and liver function indexes in young men

To understand the associations between concentrations of urinary polycyclic aromatic hydrocarbon (PAH) metabolites and liver function indexes, 121 participants were recruited from Zhengzhou City. Blood and urine samples, as well as questionnaires were collected. Blood samples were analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), total protein (TP), albumin (Alb), globulin (Glo) and albumin/globulin ratio (A/G). Urine samples were analyzed for 1-hydroxypyrene(1-OHP). Correlation coefficients, linear regression models and logistic regression models were used. The results indicated that exposure to PAHs was widespread in young men from Zhengzhou. There was weak positive correlation between urinary 1-OHP concentrations and AST. No significant correlation was found between urinary 1-OHP concentrations and other liver function indexes.