γ-radiation-induced γH2AX formation occurs preferentially in actively transcribing euchromatic loci |
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| Authors: | Raja S Vasireddy Tom C Karagiannis Assam El-Osta |
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| Institution: | (1) Epigenetics in Human Health and Disease, BakerIDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, VIC, Australia;(2) Molecular Radiation Biology, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;(3) BakerIDI Heart and Diabetes lnstitute, 75 Commercial Road, Melbourne, VIC, 3004, Australia; |
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| Abstract: | The central dogma in radiation biology is that nuclear DNA is the critical target with respect to radiosensitivity. In accordance
with the theoretical expectations, and in the absence of a conclusive model, the general consensus in the field has been to
view chromatin as a homogeneous template for DNA damage and repair. This paradigm has been called into question by recent
findings indicating a disparity in γ-irradiation-induced γH2AX foci formation in euchromatin and heterochromatin. Here, we
have extended those studies and provide evidence that γH2AX foci form preferentially in actively transcribing euchromatin
following γ-irradiation. |
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