异常黑胆质性肝癌病证模型肝硬化期的肝脏形态学研究

 为了探讨异常黑胆质体液对异常黑胆质性肝癌病证模型肝硬化期的影响，在异常黑胆质载体大鼠模型的基础上，用二乙基亚硝胺（DEN）诱发建立维吾尔医异常黑胆质性肝癌病证模型大鼠发生肝硬化，对大鼠第5、7、9、11周时肝脏的外观、病理变化和超微结构进行动态观察。结果表明，模型对照组和异常黑胆质病证模型组均经过肝细胞损伤、肝细胞增生、肝硬化等改变；但异常黑胆质病证模型组大鼠肝脏外观的变化明显快于模型对照组；在同一时间，异常黑胆质病证模型组肝细胞水肿程度、不典型增生、假小叶的形成等病理表现和糖原、线粒体减少等超微结构变化均较模型对照组严重。由此可以得出，在异常黑胆质载体大鼠模型的基础上，用DEN诱导的异常黑胆质性肝癌病证模型肝脏病变的发生过程中异常黑胆质体液可能具有促进和加快肝细胞坏死，肝细胞增生灶，肝细胞增生结节，肝硬化，直至肝细胞癌过程的作用，而这一过程接近人类肝癌的发病特点和过程。表明异常黑胆质性肝癌病证模型肝硬化期的建立具有一定的可行性。

Morphological Study on Hepatic Tissue in Hepatocirrhosis Phase of Hepatocarcinoma Carrying Abnormal Savda Model

The effect of abnormal savda on the inducing and developing process of hepatocirrhosis phase in hepatocarcinoma carrying abnormal savda model is studied under the direction of Uighur medicine, establishing the abnormal savda disease rat model serving as a base, using DEN further to establish hepatocarcinoma carrying abnormal savda disease rat model till hepatocirrhosis occurs. The surface of the liver and its pathological and ultrastructural changes in 5th, 7th, 9th, 11th weeks were dynamically observed, respectively. The results show that both in the model control group and the abnormal savda syndrome model group there is the pathological changing process of hepatoxic lesion, hepatic proliferation, hepatocirrhosis, but the pathological changes of the liver surface in the abnormal savda syndrome model group is faster than those in the model control group. At the same time point, the dropsical level of liver cell, typeless hyperplasia, the fake foliole level in liver, the ultrastructural changes of decreasing hepatin and chondriosome in liver cells in abnormal savda syndrome model group exceed those in the model control group. These findings indicate that in the process of establishing abnormal savda disease rat model serving as a base, using DEN further to establish hepatocarcinoma carrying abnormal savda disease rat model, the abnormal savda hilit accelerates the inducing and developing process of hepatocyte to hepatic cellular proliferation andU to hepatocellular carcinoma and this process is similar to the process of human hepatocarcinoma. It is also stable and reliable.