可溶性CD40配体与冠脉病变的相关性研究

目的：通过分析可溶性细胞表面分化抗原40配体（sCD40L）水平与冠脉病变的关系，探讨其在冠心病发病中的意义。方法：经冠脉造影确诊的冠心病患者，对冠脉病变程度进行分型，ELISA法检测血浆中sCD40L含量，分析sCD40L水平与冠脉病变程度的相关性。结果：CHD组与对照组相比，sCD40L明显增加，且随冠脉病变累计支数越多、病变越严重，sCD40L水平增高越明显。单因素相关分析显示sCD40L水平与病变支数、病变类型呈正相关关系。结论：sCD40L对ACS不稳定斑块有促进作用，通过检测其表达水平，可能对预测动脉粥样硬化的启动和进展、斑块的易损性等提供新的资料，最终可能指导治疗，

The Relationship of s CD40L and Coronary Artery Lesions in CHD Patients

Objective: To investigate the mechanism of s CD40L in coronary heart disease(CHD) by studying the relationship between s CD40L and the severity of coronary lesions in coronary heart disease patients.Methods: 128 patients with CHD who underwent coronary angiography were investigated.Enzyme Linked Immunosorent Assay was used to measure the level of s CD40L.The severity of coronary artery lesions was analyzed,and the lesions of coronary artery were classified.Results: s CD40L level was significantly higher in CHD patients than those in controls.The more the number of coronary artery lesions and severity of coronary artery lesions are,the higher the level of s CD40L is.Positive correlation was seen among s CD40L level and the number of coronary artery lesions and severity of coronary artery lesions.Conclusions: s CD40L accelerated the formation of unstable plaque.It would be a valuable method to predict the priming and progresss of atherosclerotic and the vulnerability of plaque in patients by detecting the level of s CD40L.