Enhanced inhibition of RNA synthesis by amanitins in in vitro cultured cells |
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Authors: | Laura Foá-Tomasi F Costanzo Gabriella Campadelli-Fiume |
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Institution: | (1) Istituto di Microbiologia e Virologia, Università di Bologna, Via San Giacomo 12, I-40126 Bologna, (Italy) |
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Abstract: | Summary The inhibition of RNA synthesis by -amanitin on vitro cultured cells is very slow. The action of various analogues of the toxin was tested and some of them proved more effective. Moreover pretreatment of cell cultures with DEAE-dextran greatly enhanced the effect of -amanitin.Acknowledgments. We thank ProfessorTh. Wieland and Dr.H. Faulstich (Max-Planck-Institut, Heidelberg) for the generous gift of amanitins. This investigation was supported by grant No. 74.00637.65 from C.N.R. (Roma). |
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