缺血性脑卒中脑温度的磁共振波谱研究

目的应用磁共振波谱成像(magnetic resonance spectroscopy,MRS)监测缺血性脑卒中卒中灶及脑干的温度变化.方法选取缺血性脑卒中患者15例,健康对照15例,分别于第1周及第8周行常规轴位T2WI,FLAIR及MRS扫描,测量卒中灶及脑干乙酰-天门冬氨酸(N-acety-L-asparticaca acid,NAA)化学位移,通过公式T=37+100(CSNAA-2.035)计算相应脑区温度,观察并对比分析数值的变化.结果患者卒中灶温度第1周高于第8周,差异具有统计学意义(P0.05);卒中灶温度第1周高于健康志愿者相应脑区,差异具有统计学意义(P0.05).结论 MRS能从分子水平研究缺血性脑卒中患者脑区温度变化,并有望用于评价临床疗效.

On Brain Temperature Changes in the Patients with Cerebral Ischemic Stroke by Magnetic Resonance Spectroscopy

Objective To monitor brain temperature changes in different brain regions in the patients with cerebral ischemic stroke by magnetic resonance spectroscopy ( MRS ) . Method Fifteen patients with recent cerebral infarction and fifteen healthy volunteers were enrolled. Conventional T2-weighted imaging (T2WI),fluid-attenuated inversion recovery ( FLAIR) and MRS scans were performed at the first week and the eighth week. The chemical shifts of N-acety-L-asparticaca acid in the stroke focus and brain stem were determined. The brain temperatures were calculated according to T=37+100(CSNAA-2. 035),and the changes were analyzed. Results The temperature in ischemic area at the first week was higher than that at the eighth week (P<0. 05). Compared with the healthy group,the temperature in ischemic area of the stroke group at the first week was much higher(P<0. 05). Conclusion MRS can provide information from molecular level for the progress of brain temperature changes and the evaluation of treatment.