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| 阿伐那非类似物的合成与表征 | |
| 作者单位： | ;1.河南工业大学生物工程学院 |
| 摘 要： | 以4-(3-氯-4-甲氧基苄基氨基)-2-[(2S)-2-羟甲基-1-吡咯烷基]-5-嘧啶羧酸乙酯为原料,在VDMSO∶VTHF=1∶1的混合溶液中,水解成酸后,与不同的胺反应,合成了8种未见文献报道的阿伐那非类似物.所合成的产物经~1H NMR、~(13)C NMR、ESI-MS得到验证. |
| 关 键 词： | 阿伐那非类似物 酰胺缩合 合成 |
Synthesis and Characterization of Avanafil Analogues |
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| Affiliation: | ,College of Biological Engineering,Henan University of Technology |
| Abstract: | The 8 kinds of no literature reports of avanafil analogues were synthesized by amidation of amines and hydrolyzate of 4-[( 3-chloro-4-methoxybenzyl) amino]-2-[( 2S)-2-hydroxymethyl-1-pyrrolidinyl]-5-pyrimidineethylformate( 1),which hydrolyzed in mixed solvent( VDMSO∶ VTHF= 1 ∶ 1). Their structure was characterized by1 H NMR,13 C NMR and ESI-MS. |
| Keywords: | avanafil analogues amide condensation synthetic |
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