Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon! |
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| Authors: | W Liedtke C Kim |
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| Institution: | (1) Center for Translational Neuroscience, Department of Neurobiology, Department of Medicine/Division of Neurology, Duke University Medical Center, Bryan Research Building, Room 201G, Durham, North Carolina 27710, USA;(2) Hormone Research Center, School of Biological Sciences, Chonnam National University, Yongbong-Dong, Buk-Gu, KwangJu-Si, South Korea |
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| Abstract: | Transient receptor potential (TRP) ion channels have been identified as cellular sensors responding to diverse external and
internal stimuli. This review will cover the TRPV subfamily that comprises vertebrate and invertebrate members. The six mammalian
TRPV channels were demonstrated to function in thermosensation, mechanosensation, osmosensation and Ca2+ uptake. Invertebrate TRPV channels, five in Caenorhabditis elegans and two in Drosophila, have been shown to play a role in mechanosensation, such as hearing and proprioception in Drosophila and nose touch in C. elegans, and in the response to osmotic and chemical stimuli in C. elegans. We will focus here on the role that TRPV ion channels play in mechanosensation and a related sensory (sub-)modality, osmosensation.
Received 2 May 2005; received after revision 30 July 2005; accepted 30 August 2005 |
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| Keywords: | TRP TRPV mechano-TRP osmo-TRP C elegans Drosophila TRPV4 OSM-9 OCR-2 NAN IAV |
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