| 以超临界CO2为稀释剂的胆红素重结晶提纯 |
| |
| 引用本文： | 蔡建国,杨中文,周展云.以超临界CO2为稀释剂的胆红素重结晶提纯[J].华东理工大学学报(自然科学版),1994,20(3):317-321. |
| |
| 作者姓名： | 蔡建国 杨中文 周展云 |
| |
| 作者单位： | 华东理工大学化学工程研究所 |
| |
| 摘 要： | 以二甲基亚矾(DMSO)为溶剂，以超临界CO2为稀释膨胀剂，重结晶提纯胆红素。考察了DMS0膨胀度对胆红素溶解能力的影响。结果表明，胆红素的DMSO溶液经超临界CO稀释膨胀至3倍后，DMSO对胆红素的溶解能力显著下降。用不同的温度、压力、溶液加入量等备件，能有效地控制DMSO的稀释膨胀程度，从而在短时间内形成较大的过饱和度；使胆红素析出，分离母液后，获得长度<1um，直径<0．5um和颗粒较均匀的胆红素纯度太于90%
|
| 关 键 词： | 超临界流体 CO2 稀释剂 胆红素 重结晶 提纯 |
Refining of Bilirubin with Supercritical Carbon Dioxide Antisolvent Recrystallization |
| |
| Cai Jianguo, yang Zhongwen and Zhou Zhanyun.Refining of Bilirubin with Supercritical Carbon Dioxide Antisolvent Recrystallization[J].Journal of East China University of Science and Technology,1994,20(3):317-321. |
| |
| Authors: | Cai Jianguo yang Zhongwen and Zhou Zhanyun |
| |
| Abstract: | The process of recrystallization with supercritical carbon dioxide as an anti-solvent agent was studied.The expansion of Dimethyl Sulphoxide(DMSO)influencing the solubility of Bilirubin was discussed.The results showed:In different temperature,pressure and different amount of solvent can form different supersaturation ratio.When the DMSO solution of bilirubin is expanded and then the solvent is extracted, it can obtain a particle less than lum with bilirubin content more than ninety percent.It appears to be a reliable and effeclive method for refining of biologically active products and micronizing. |
| |
| Keywords: | bilirubin supercritical fluid carbon dioxide refining recrystallization |
| 本文献已被 CNKI 维普 等数据库收录！ |
