| Two forms of the membrane-bound state of the first C2 domain (C2A) of synaptotagminⅠand calcium-triggered membrane insertion |
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| 作者姓名： | HE Yuhong LI Xianghui WANG Fu XUE Yi & SUI Senfang |
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| 作者单位： | HE Yuhong，LI Xianghui，WANG Fu，XUE Yi & SUI Senfang Department of Biological Sciences & Biotechnology，State Key Labora-tory of Biomembrane，Tsinghua University，Beijing 100084，China |
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| 摘 要： | Neurotransmitter release from presynaptic neurons into the synaptic cleft is an essential step in neurotrans-mission. The release is triggered by Ca2+ and completed by the fusion of neurotransmitters containing synaptic vesicles with the presynaptic membrane. Over the last decades, there has been a virtual explosion in identifica-tion of proteins that play critical roles in the release proc-ess. The leading candidates proposed as the Ca2+-sensors that regulate fusion are members of the synapt…
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| 关 键 词： | synaptotagminⅠ lipid monolayer critical insertion pres- sure immunofluorescence staining Western blot. |
Two forms of the membrane-bound state of the first C2 domain (C2A) of synaptotagminⅠand calcium-triggered membrane insertion |
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| HE Yuhong,LI Xianghui,WANG Fu,XUE Yi & SUI Senfang.Two forms of the membrane-bound state of the first C2 domain (C2A) of synaptotagminⅠand calcium-triggered membrane insertion[J].Chinese Science Bulletin,2003,48(17). |
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| Authors: | HE Yuhong Li Xianghui WANG Fu XUE Yi SUI Senfang |
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| Abstract: | |
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| Keywords: | lipid monolayer critical insertion pres-sure immunofluorescence staining Western blot |
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