靶向细胞凋亡的海洋抗肿瘤多肽药物研究进展

凋亡在肿瘤的形成和发展中具有重要功能,靶向凋亡通路已成为发展化疗药物的重要策略。海洋生物多肽是抗肿瘤药物的重要来源,并且已经发现的大多数抗肿瘤海洋多肽都可以通过诱导凋亡途径发挥抗肿瘤作用。本文针对这类海洋药物研发中存在的药物抗原性及药物来源等主要问题,综述了近年来发现的海洋多肽及其诱导细胞凋亡的信号通路。

Research advances of marine antitumor peptides targeting apoptosis

Apoptosis plays an important role in formation and development of a cancer. Targeting apoptotic pathway has become a significant strategy for developing chemotherapeutic agents. Marine peptides is an important source for antitumor drugs, most of which can exert antitumor effect by inducing apoptotic pathway. We survey recently discovered marine peptides and apoptotic signal pathway for drug antigenicity and drug sources in the development for such marine drugs.