| PLGA的合成、表征及其导管支架的制备 |
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| 引用本文： | 申雄军,阮建明,周忠诚,邹俭鹏.PLGA的合成、表征及其导管支架的制备[J].长沙理工大学学报(自然科学版),2008,5(2):93-96. |
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| 作者姓名： | 申雄军 阮建明 周忠诚 邹俭鹏 |
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| 作者单位： | 1. 中南大学粉末冶金国家重点实验室,湖南,长沙410083;长沙理工大学,化学与环境工程学院,湖南,长沙410076
2. 中南大学粉末冶金国家重点实验室,湖南,长沙410083 |
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| 摘 要： | 用质量百分比为80％的L-丙交酯与20％的乙交酯进行开环聚合，得到聚（L-丙交酯-CO-乙交酯）（80／20），并用红外光谱和氢核磁共振光谱进行了表征．对合成条件与PLGA相对分子量的关系进行了研究．研究结果表明，合成高分子量PLGA的最优条件是：聚合温度为140℃，反应时间为48h，单体与引发剂的摩尔比（n（M）／n（I））为8000／1．结合溶液浇铸与盐沥滤技术，PLGA被制作成多孔导管支架．PLGA导管支架具有相互连通的孔墙结构．
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| 关 键 词： | 聚(L-丙交酯-co-乙交酯) 生物材料 制备 多孔导管支架 |
Synthesis and characterization of PLGA and preparation of PLGA conduits |
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| SHEN Xiong-jun,RUAN Jian-ming,ZHOU Zhong-cheng,ZOU Jian-peng.Synthesis and characterization of PLGA and preparation of PLGA conduits[J].Journal of Changsha University of Science and Technology:Natural Science,2008,5(2):93-96. |
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| Authors: | SHEN Xiong-jun RUAN Jian-ming ZHOU Zhong-cheng ZOU Jian-peng |
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| Institution: | SHEN Xiong-jun, RUAN Jian-ming,ZHOU Zhong-cheng,ZOU Jian-peng(1. State Key Laboratory of Power Metallurgy,Central South University, Changsha 410083,China ; 2. College of Chemistry and Environment Engineering,Changsha University of Science and Technology,Changsha 410076 ,China) |
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| Abstract: | Poly（L--lactide--co--glycolide） （80/20） was synthesized by ring-opening copoly-merization from 80 % （wt） L--lactide and 20%（wt） glycolide and characterized by infrared spectrum and proton nuclear magnetic resonance spectrum. The relationship between relative molecular mass of PLGA and polymerization conditions was investigated. The results showed that the optimum polymerization conditions to obtain the great relative molecular mass of PLGA is the following： polymerization temperature is 140℃, reaction time is 48 hs, and the mole ratio of monomer to initiator （n （M）/n （I）） is 8 000/1. PLGA was manufactured into porous biodegradable conduits using a combined solvent casting and par-ticulate leaching technique. PLGA conduits have an interconnected pore structure. |
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| Keywords: | poly （L--lactide--co--glycolide） biomaterial preparation porous conduit |
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