| LC-MS/MS快速筛查中毒药物及典型病例分析 |
| |
| 引用本文： | 李鹏飞,吴诚,马萍,刘丽宏,王玲,王彦峰,高文静.LC-MS/MS快速筛查中毒药物及典型病例分析[J].北京师范大学学报(自然科学版),2010,46(4). |
| |
| 作者姓名： | 李鹏飞 吴诚 马萍 刘丽宏 王玲 王彦峰 高文静 |
| |
| 作者单位： | 第二炮兵总医院药学部,100088,北京;第二炮兵总医院药学部,100088,北京;第二炮兵总医院药学部,100088,北京;第二炮兵总医院药学部,100088,北京;第二炮兵总医院药学部,100088,北京;第二炮兵总医院药学部,100088,北京;第二炮兵总医院药学部,100088,北京 |
| |
| 摘 要： | 建立血液中常见中毒药物的快速、高效LC-MS/MS筛查方法. 采用沉淀蛋白的前处理方法,通过相关信息扫描模式,运用多反应监测作筛查,再依赖3个不同能量的增强型二级碎片离子扫描,最终在数据库中筛选中毒药物.结果表明:优化LC-MS/MS快速筛查方法,节省了检测时间,已成功地进行毒物检测分析,为临床抢救赢得了时间、提供了有力的依据.本方法可用于中毒患者的毒物药物定性分析.
|
| 关 键 词： | 高效液相色谱-串联质谱 药物中毒 快速筛查 |
LC-MS/MS FAST SCREENING OF DRUG POISONS TYPICAL APPLICATIONS |
| |
| LI Pengfei,WU Cheng,MA Ping,LIU Lihong,WANG Ling,WANG Yanfeng,GAO Wenjing.LC-MS/MS FAST SCREENING OF DRUG POISONS TYPICAL APPLICATIONS[J].Journal of Beijing Normal University(Natural Science),2010,46(4). |
| |
| Authors: | LI Pengfei WU Cheng MA Ping LIU Lihong WANG Ling WANG Yanfeng GAO Wenjing |
| |
| Institution: | LI Pengfei WU Cheng MA Ping LIU Lihong WANG Ling WANG Yanfeng GAO Wenjing(Department of Pharmacy,General Hospital of the Second Artillery,PLA,100088,Beijing,China) |
| |
| Abstract: | The aim of this work was to establish qualitative screen for common drug poisons in blood by LC-MS/MS.Samples were treated by acetonitrile precipitation to remove protein.The scan was carried out with multiple reaction monitoring and enhanced product ion scan in a information-dependent acquisition mode.Drug was identified by library search with a newly developed MS/MS library based on EPI at three different collision energies in positive mode.The method has been successfully used in drug poison detection by... |
| |
| Keywords: | LC-MS/MS drug poison fast screening |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
