| (1→3)-α-D葡聚糖的季铵盐合成及其抗菌活性(1→3)-α-D葡聚糖的季铵盐合成及其抗菌活性 |
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| 引用本文： | 王天奇,李翰祥,姚进孝,谭天伟.(1→3)-α-D葡聚糖的季铵盐合成及其抗菌活性(1→3)-α-D葡聚糖的季铵盐合成及其抗菌活性[J].北京化工大学学报(自然科学版),2007,34(4):418-420. |
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| 作者姓名： | 王天奇 李翰祥 姚进孝 谭天伟 |
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| 作者单位： | 北京化工大学生命科学与技术学院， 北京 100029 |
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| 摘 要： | 来源于Penicillium chrysongenum的碱溶性 (1→3)-α-D葡聚糖与缩水甘油基三甲基季铵盐酸盐（glycidyl trimethylammonium chloride, GTMAC）反应，生成葡聚糖季铵盐。IR图谱中季铵基团上的甲基的变角振动峰1480cm-1、伸缩振动峰2872cm-1变化明显，1H-NMR表征确定季铵基团在糖环2、4位连接。该葡聚糖的最低抑菌浓度对大肠杆菌为1.0mg/mL，对金黄色葡萄球菌为2.0mg/mL。细胞质释放检测结果显示，葡聚糖季铵盐通过作用于细菌细胞膜而发挥抗菌作用。
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| 关 键 词： | (1→3)-α-D葡聚糖 季铵盐 抗菌活性 1H NM (1→3)-α-D葡聚糖 季铵盐 抗菌活性 1H NM |
| 修稿时间： | 2007-01-25 |
Synthesis of quaternary ammonium-glucan and its qantibacterial activity |
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| WANG TianQi,LI HanXiang,YAO JinXiao,TAN TianWei.Synthesis of quaternary ammonium-glucan and its qantibacterial activity[J].Journal of Beijing University of Chemical Technology,2007,34(4):418-420. |
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| Authors: | WANG TianQi LI HanXiang YAO JinXiao TAN TianWei |
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| Institution: | College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China |
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| Abstract: | Quaternary ammonium-glucan has been synthesized by the reaction between glycidyl trimethylammonium chloride (GTMAC) and alkali soluble (1→3)-α-D glucan isolated from Penicillium chrysongenum. Quaternary ammonium glucan showed a methyl C—H bending vibration at 1480cm-1 and stretching vibration at 2872cm-1 in its IR spectrum. The quaternary ammonium group is linked with the 3and 4positions in the glucose ring according to 1H-NMR experiments. The minimum inhibitory concentrations (MIC) of quaternary ammonium glucan were 2.0mg/mL and 1.0mg/mL for Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC8099, respectively. The antibacterial action is associated with an interaction with the cell membrane. |
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| Keywords: | (1→3)-α-Dglucan quuaternary ammonium salt anti bacterial activity 1H NMR |
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