| Preparation of molecularly imprinted microspheres by photo-grafting on supports modified with iniferter |
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| 作者姓名： | RONG Fei FENG Xiaogang LI Ping YUAN Chunwei FU Degang |
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| 作者单位： | [1]State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China [2]Bioengineering Department, Beijing University of Aeronautics and Astronautics, Beijing 100083, China |
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| 基金项目： | Acknowledgements This work was supported by the National Natural Science Foundation of China （Grant No. 60121101）. |
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| 摘 要： | Molecularly imprinted microspheres (MIMs) of D-mandelic acid were synthesized in this study. Chloromethylated polystyrene beads modified with iniferter were used as supports for photo-grafting of a molecularly imprinted polymer (MIP) layer. The polymers were characterized by FT-IR, elemental analysis and thermo-gravimetric analysis to testify the polymer formation and its thermal stability. Scan- ning electron micrographs (SEM) show that the MIP particles are mono-dispersed and well-spherical, with the average diameter of 4.38 μm and size distribution coefficient of 1.02. Furthermore, the MIMs were packed in a stainless steel column and evaluated as stationary phases in high performance liquid chro- matography (HPLC). The prepared MIP exhibited a considerable capability of chiral separation between template and its enantiomer. Accordingly, this kind of MIP is likely to have wide applications in chemical sensing, chromatographic analysis and solid phase extraction.
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| 关 键 词： | MIMs 聚苯乙烯 引发-转移-终止剂 照相-移植法 生物电子学 |
| 文章编号： | 10.1007/s11434-006-2170-5 |
| 收稿时间： | 2006-03-06 |
| 修稿时间： | 2006-03-062006-06-12 |
Preparation of molecularly imprinted microspheres by photo-grafting on supports modified with iniferter |
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| RONG Fei FENG Xiaogang LI Ping YUAN Chunwei FU Degang.Preparation of molecularly imprinted microspheres by photo-grafting on supports modified with iniferter[J].Chinese Science Bulletin,2006,51(21):2566-2571. |
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| Authors: | Fei Rong Xiaogang Feng Ping Li Chunwei Yuan Degang Fu |
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| Institution: | (1) State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China;(2) Bioengineering Department, Beijing University of Aeronautics and Astronautics, Beijing, 100083, China |
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| Abstract: | Molecularly imprinted microspheres (MIMs) of D-mandelic acid were synthesized in this study. Chloromethylated polystyrene beads modified with iniferter were used as supports
for photo-grafting of a molecularly imprinted polymer (MIP) layer. The polymers were characterized by FT-IR, elemental analysis
and thermo-gravimetric analysis to testify the polymer formation and its thermal stability. Scanning electron micrographs
(SEM) show that the MIP particles are mono-dispersed and well-spherical, with the average diameter of 4.38 μm and size distribution
coefficient of 1.02. Furthermore, the MIMs were packed in a stainless steel column and evaluated as stationary phases in high
performance liquid chromatography (HPLC). The prepared MIP exhibited a considerable capability of chiral separation between
template and its enantiomer. Accordingly, this kind of MIP is likely to have wide applications in chemical sensing, chromatographic
analysis and solid phase extraction. |
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| Keywords: | molecularly imprinted microspheres polystyrene beads iniferter photo-grafting |
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