Effects of prolactin (PRL) on gonadotropin release in mice with congenital PRL deficiency

Summary In prolactin (PRL)-deficient male dwarf mice, treatment with PRL stimulates the release of FSH without affecting plasma LH levels. We now report that this effect of PRL is not mediated by the testes and that PRL does not modify FSH or LH release in female dwarf mice.This work was supported by the National Institute of Child Health and Human Development through a grand HD12642 and RIA Core of grant HD10202. We thank NIAMDD and Drs G.D. Niswender and L.E. Reichert, Jr, for reagents used in radioimmunoassays.