More on the need for circadian,circaseptan and circannual optimization of cyclosporine therapy |
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| Authors: | T. Liu M. Cavallini F. Halberg G. Cornelissen J. Field D. E. R. Sutherland |
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| Affiliation: | (1) University of Minnesota, 55455 Minneapolis, Minnesota, USA;(2) Bethune Medical College, Changchun, (People's Republic of China);(3) University of Rome, Rome, (Italy) |
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| Abstract: | ![]()
Summary Cyclosporine chronotherapy of pancreas-allotransplanted rats revealed, beyond a circadian stage-dependence of equal daily doses, further gain in graft function from doses varying from day to day with an about 7-day periodicity, the first highest dose being given on the 3rd or 5th day after surgery. |
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| Keywords: | Pancreatic allograft cyclosporine chronotherapy circadian circaseptan circannual |
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