Strategy against micrometastasis of epithelial cancer: Detection and elimination |
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Authors: | Li Qin Yi Xiao Yinghua Chen |
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Institution: | (1) Laboratory of Immunology, Research Centre for Medical Science and Department of Biology, Tsinghua University, Protein Science Laboratory of MOE, 100084 Beijing, China |
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Abstract: | Tumor metastasis is generally agreed to be the major cause of cancer death. Over the last few years, studies of new diagnosis
techniques and tumor immunotherapy have made great progress. Recent clinical studies on the occult metastases of breast, lung
and colorectal cancer all suggested that the detection of micrometastases in bone marrow is prognostically important and provides
substantial evidence of tumor dissemination. On the other hand, two kinds of the mAb-based immunotherapy have been approved
for the treatment against epithelial cancer. Monoclonal antibody (mAb) 17-1A for colorectal carcinomas and mAb herceptin for
breast cancer both have produced good curative effects. Potential therapeutics based on some antibodies with prominent antitumor
activity also has shown obvious clinical effect. These studies indicate that detection of micrometastasis in circulatory system
and immunotherapy by eliminating metastatic malignant cells suggested a new strategy against the metastatic cancer. |
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Keywords: | tumor micrometastasis detection elimination immunotherapy mAb |
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