丹酚酸B对妊高征大鼠的影响

目的 研究丹酚酸B对妊高征的治疗作用.方法 将45只妊娠后的大鼠随机分为正常妊娠组、模型对照组及丹酚酸B组，内毒素法造成妊高征模型，同时丹酚酸B组每日尾静脉注射丹酚酸B 22.5 mg/kg，给药期间各组大鼠每隔2 d测量血压及24 h尿蛋白量，妊娠第20天处死动物检查胎盘重量及孕鼠数.结果 丹酚酸B组大鼠血压及24 h尿蛋白量明显低于模型对照组，胎盘明显重于模型对照组，孕鼠数也明显增多.结论 丹酚酸B对妊高征有很好的治疗作用.

Effects of Salvianolic Acid B on Pregnancy-Induced Hypertension in Rats

45 pregnant rats were randomly divided into normal pregnant groups,model groups and Salvianolic acid B(Sal B)-treated groups.Pregnancy-induced Hypertension(PIH) rats model were induced by endotoxin infusing via caudal vein,and Sal B had been administered to the therapy groups at 22.5 mg·kg-1 per day.The blood pressure and 24 hours urine protein of three groups of rats were recorded every two days.All of the rats were killed;the number of fetal rats and the weight of placenta were measured on the 20th day of gestation.The results showed that blood pressure and 24 hours urine protein in Sal B-treated groups were obviously lower than those in model groups,the number of fetal rats was much more and the weight of placenta was heavier.So the research indicates that Sal B can be used to treat PIH.