比格犬深静脉穿刺置管模型的建立及应用

目的 建立比格犬深静脉穿刺置管模型，探讨其应用范围。方法 将8只成年比格犬随机分成股静脉穿刺置管组(股静脉组)和颈内静脉穿刺置管组(颈内静脉组)，每组4只。对比格犬行1.5%～3%异氟烷和氧气混合吸入麻醉后，取仰卧位固定于手术台上，定位股静脉或颈内静脉，行经皮深静脉穿刺置管术并固定导管。结果 行深静脉穿刺置管术的8只比格犬全部置管成功，术中麻醉效果良好，股静脉穿刺置管较颈内静脉穿刺置管操作方便，手术时间短，术后便于护理，并发症少。结论 比格犬深静脉穿刺置管模型的建立，实现了血液灌流及血液净化等技术在实验动物身上的应用，为开展相关临床基础研究提供方便，也可应用于兽医对中毒犬行血液灌流或血液净化，对休克犬进行快速大量补液等。

Establishment and Application of an Animal Model through Deep Venous Puncture Catheterization (DVPC) in Beagles

Objective To establish an animal model through DVPC in beagles and to discuss its field of application. Method Eight adult beagles were randomly divided into the group of femoral vein catheterization (FVC) and the group of jugular vein catheterization (JVC), each group with four beagles. After anesthesia with a mixture of 1.5%-3% (v/v) isoflurane and oxygen, the beagles were fixed with a supine position in the operating table.The femoral vein and jugular were positioned to carry out DVPC and the catheters were fastened. Result DVPC for eight beagles was successful and the anesthetic effect was good. Compared with JVC, FVC operates more conveniently with shorter operating time, easier nursing and fewer complications. Conclusion The establishment of DVPC in beagles makes it possible for the application of blood perfusion and purification to laboratory animals. Meanwhile, it facilitates relevant clinical basic research. It can also be applied by vets to poisoned dogs for blood perfusion or purification and also to shock dogs for quick and mass fluid infusion.