Application of EEG multipole model in the diagnosis of Alzheimer’s disease

In order to find the electroencephalogram (EEG) characteristic parameters typical of Alzheimer’s disease (AD) and explore an effective diagnostic method, a new mobile current multipole model was proposed to simulate the AD patient’s cortical dipole source activities. The indicators of goodness of fit (GOF) and DtononD (DD) were calculated from EEG samples to evaluate the performance of this model. Relevant results showed that this multipole model with higher GOF values and larger DD change well fitted the pathological electrical activities of cortical neurons aroused by AD’s extended sulcus and gyrus in the cerebral cortex. Meanwhile, the products of DD mean & standard variance were found in a clear linear correlation with the diagnostic data of mini-mental state examination (MMSE) used in AD clinics. Furthermore, by tracing this multipole model’s indicators in typical patients and contrasting with the functional magnetic resonance image (fMRI) as AD progressed, we suggested that the DD index may be suitable for monitoring the AD developments as a new diagnostic parameter.