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Molecular cloning and expression of cDNAs for the human interleukin-2 receptor |
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| Authors: | W J Leonard J M Depper G R Crabtree S Rudikoff J Pumphrey R J Robb M Kr?nke P B Svetlik N J Peffer T A Waldmann |
| Abstract: | We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNAs which differ in their polyadenylation signals. We have isolated an additional cDNA that may correspond to an alternatively spliced mRNA that lacks a 216 base segment and appears to encode an altered membrane protein which cannot bind interleukin-2. |
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