| 松杉灵芝多糖的抗突变作用 |
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| 引用本文： | 郑克岩,张洁,林相友,李芳亮,由宇润,费晓方.松杉灵芝多糖的抗突变作用[J].吉林大学学报(理学版),2005,43(2):235-237. |
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| 作者姓名： | 郑克岩 张洁 林相友 李芳亮 由宇润 费晓方 |
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| 作者单位： | 吉林大学,公共化学教学与研究中心,长春,130023;长春中医学院,药学院,长春,130117;吉林大学,生命科学学院生物制药系,长春,130023;国家新药沈阳安全评价研究中心,沈阳,110021 |
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| 基金项目： | 吉林省科技发展计划重大科技攻关项目基金(批准号:200205038) |
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| 摘 要： | 通过小鼠骨髓细胞微核试验、 小鼠睾丸染色体畸变和Ames 试验观察了松杉灵芝多糖的抗突变作用. 结果表明， 松杉灵芝多糖对TA98, TA100两株试验菌株， 加与不加S-9均对阳性物致突变作用有抑制作用；
口服不同剂量的药液30 d， 能明显拮抗环磷酰胺所致小鼠骨髓细胞微核率， 但对于丝裂霉素C诱发小鼠睾丸染色体畸变无明显抑制作用.
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| 关 键 词： | 松杉灵芝多糖 抗突变 畸变 |
| 文章编号： | 1671-5489(2005)02-0235-03 |
| 收稿时间： | 2004-07-13 |
| 修稿时间： | 2004年7月13日 |
Anti-mutagenic Effects of Polysaccharides from Ganoderma Tsugae |
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| ZHENG Ke-yan,ZHANG Jie,LIN Xiang-you,LI Fang-liang,YOU Yu-run,FEI Xiao-fang.Anti-mutagenic Effects of Polysaccharides from Ganoderma Tsugae[J].Journal of Jilin University: Sci Ed,2005,43(2):235-237. |
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| Authors: | ZHENG Ke-yan ZHANG Jie LIN Xiang-you LI Fang-liang YOU Yu-run FEI Xiao-fang |
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| Institution: | 1. Teaching and Research Center of Chemistry, Jilin University, Changchun 130023, China;2. Department of Biology Pharmaceutics, College of Life Sciences, Jilin University, Changchun 130023, China; 3. National New Drug Safety Estimate Center, Shenyang 110021, China; 4. College of Pharmaceutics, Changchun College of Traditional Chinese Medicine, Changchun 130117, China |
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| Abstract: | The anti-mutagenic effects of polysaccharides from Ganoderma tsugae were studied by mice bone marrow cell micronuclei test, mice testicular chromosome aberration test and Ames test. The micronuclei frequency induced by cyclophosphamide in mouse bone marrow cells was inhibited significantly, but mouse testicular chromosome aberration frequency induced by mitomycinc was not inhibited markedly by polysaccharides from Ganoderma tsugae. The Ames test showed that polysaccharides from Ganoderma tsugae have effectively anti-mutagenic activties. |
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| Keywords: | polysaccharides from Ganoderma tsugae anti-mutagenic aberration |
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