Action of histamine and vasoactive intestinal peptide (VIP), on cyclic AMP in gastric glands isolated from human fetal stomach |
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| Authors: | C. Gespach C. Dupont G. Rosselin |
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| Affiliation: | (1) Unité de Recherche de Diabétologie et d'Etudes Radio-Immunologiques des Hormones Protéiques (INSERM U.55, CNRS ERA 494), Hôpital Saint-Antoine 184, rue du Fg Saint-Antoine, F-75571 Paris Cedex 12, France |
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| Abstract: | ![]()
Summary Histamine and VIP produce an elevation of cAMP production in gastric glands isolated from the human fetal stomach at 15 weeks of gestation. These effects were attributed to the activation of 2 distinct receptor-cAMP systems, one being sensitive to histamine in parietal cells, and the other being sensitive to VIP in muco-peptic cell populations. The results suggest that histamine and VIP may play a role in inducing gastric secretion during fetal life in man. |
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