| 崩解剂羧甲基淀粉的固相合成及性能 |
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| 引用本文： | 陈广德.崩解剂羧甲基淀粉的固相合成及性能[J].西北师范大学学报,2001,37(3):48-52. |
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| 作者姓名： | 陈广德 |
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| 作者单位： | 陈广德（西北师范大学化学化工学院，甘肃兰州 730070） |
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| 基金项目： | 甘肃省自然科学基金资助项目(ZR-96-019) |
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| 摘 要： | 对崩解剂羧甲基淀粉（CMS）固相合成方法进行了研究，筛选了固相合成CMS用催化剂，合成了医药用崩解剂羧甲基淀粉，考察了碱和一氯乙酸用量对CMS取供度（DS）的影响及DS和CMS中游离羧基和成盐羧基比（H／Na）对崩解剂吸水溶胀性能的影响。实验表明，该合成方法与溶液相比，节约了有机溶剂，降低了生产成本，提高了产品质量和收率。
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| 关 键 词： | 淀粉 羧甲基淀粉 固相合成 崩解 |
| 文章编号： | 1001-988Ⅹ(2001)03-0048-05 |
| 修稿时间： | 2000年12月15 |
Synthesis of disintegrator carboxymethyl starch
with solid state process and its performances |
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| CHEN Guang,de.Synthesis of disintegrator carboxymethyl starch
with solid state process and its performances[J].Journal of Northwest Normal University Natural Science (Bimonthly),2001,37(3):48-52. |
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| Authors: | CHEN Guang de |
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| Abstract: | Synthesis of disintegrator carboxymethyl starch(CMS)with solid phase synthesis method is studied.Catalyst of solid phase synthesis has been selected,and tablets disintegrator carboxymethyl starch has been synthesized.The influence of the use level of base and monochloroacetic acid on the degree of substitution(DS) in CMS,the influence of DS and H/Na(ratio of free and salified carboxylic acid in CMS)on swelling and disintegrating of CMS have been discussed.The results show that the solid phase synthesis can not only economize solvent,reduce production costs,but also improve the quality of products and collection percentage. |
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| Keywords: | starch carboxymethyl starch solid phase synthesis disintegrating |
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