灵芝黄芪复配物提高环磷酰胺对荷瘤小鼠的疗效

研究灵芝(Ganoderma lucidum)黄芪(Astragalus)复配物对环磷酰胺(cyclophosphamide,CTX)治疗的荷瘤小鼠肿瘤和免疫功能的影响.建立小鼠S180肉瘤模型,每日灌胃低、中、高剂量的灵芝黄芪复配物,并配合腹腔注射CTX.连续处理小鼠2周后,分析抑瘤效应,测定小鼠脾指数、胸腺指数、外周血白细胞(white blood cell,WBC)数和红细胞(red blood cell,RBC)数等免疫指标.同单CTX治疗组相比,中、高剂量的灵芝黄芪复配物能显著加强CTX对小鼠S180肉瘤的抑制作用(P<0.01),明显改善CTX引起的小鼠胸腺萎缩(P<0.01)和白细胞减少症状(P<0.05,P<0.01).灵芝黄芪复配物对CTX的抑瘤治疗具有明显的增效减毒作用,其效果堪比于单味中药灵芝提取物辅助CTX的抑瘤疗效,可大大降低单味灵芝提取物的治疗成本,经济价值可观.

Efficacy of Compound of Ganoderma lucidum and Astragalus Extracts on Tumor-Bearing Mice Treated by Cyclophosphamide

Effects of the compound of Ganoderma lucidum and Astragalus extracts on immunity and tumor of mice treated by cyclophosphamide(CTX) were investigated.The mice were given both compounds of Ganoderma lucidum and Astragalus extracts by gavage and CTX by peritoneal injection for two weeks after the mouse model bearing S180 tumor were produced.Then the anti-tumor effect,the thymus index,spleen index and the amount of white blood cells(WBCs) and red blood cells(RBCs) were observed and determined.Compared with the CTX group,the middle and high dose group of Ganoderma lucidum and Astragalus extracts significantly enhanced the effect of CTX on inhibiting the growth of S180 tumor(P<0.01),and prominently relieve thymic atrophy(P<0.01) and leucopenia(P<0.05,P<0.01) caused by CTX in mice.The compound of Ganoderma lucidum and Astragalus extracts showed synergy and attenuation of CTX in tumor therapy.Its efficacy was equivalent to that of single folium Ganoderma lucidum extract,which largely reduced the cost of single folium Ganoderma lucidum extract with a great economical value.